TRANSIENT IMMUNOHISTOCHEMICAL LABELING OF RAT RETINAL AXONS DURING WALLERIAN DEGENERATION BY A MONOCLONAL-ANTIBODY TO NEUROFILAMENTS

Authors
MELLER D EYSEL UT SCHMIDTKASTNER R
Citation
D. Meller et al., TRANSIENT IMMUNOHISTOCHEMICAL LABELING OF RAT RETINAL AXONS DURING WALLERIAN DEGENERATION BY A MONOCLONAL-ANTIBODY TO NEUROFILAMENTS, Brain research, 648(1), 1994, pp. 162-166
Citations number
31
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
648
Issue
1
Year of publication
1994
Pages
162 - 166
Database
ISI
SICI code
0006-8993(1994)648:1<162:TILORR>2.0.ZU;2-3
Abstract
Immunohistochemical labelling with the monoclonal antibody SMI32 to no n-phosphorylated epitopes on neurofilament proteins of high molecular weight class was low in rat central optic fibers of controls. After un ilateral transection of optic nerve, a strong, transient increase of l abelling with SMI32 occurred in degenerating fibers of optic tract at 2 and 4 days, which then declined at 8 and remained low at 21 days. Co nsequently, immunostaining with SMI32 may serve as a positive marker f or degenerating fibers in rat optic system.