GENOMIC STRUCTURE AND ORGANIZATION OF A Q-LIKE GENE IN THE GRC-G C REGION OF THE RAT/

In the rat homologue of the mouse Q/TL region, grc-G/C, a TL-like gene (RT1.N) has been identified recently. This paper reports on a Q-like gene, designated RT1.0, that maps in the same region. It contains a 5' untranslated region (UT), signal peptide, alpha 3 domain, transmembra ne region, cytoplasmic domain (three exons) and 3' UT region. Comparis on with mouse class-I genes shows that the greatest similarity is to t he H-2Q, K, D and L genes; it is very different from the TL genes of t he mouse and rat. A sequence that includes many CT repeats occurs in t he 3'UT region of RT1.0 and in three to five other class I-hybridizing fragments. Thus, the MHC-linked region of the rat contains both Q-lik e and TL-like class-I genes.