Jj. Rushton et al., GENOMIC STRUCTURE AND ORGANIZATION OF A Q-LIKE GENE IN THE GRC-G C REGION OF THE RAT/, European journal of immunogenetics, 21(3), 1994, pp. 189-198
In the rat homologue of the mouse Q/TL region, grc-G/C, a TL-like gene
(RT1.N) has been identified recently. This paper reports on a Q-like
gene, designated RT1.0, that maps in the same region. It contains a 5'
untranslated region (UT), signal peptide, alpha 3 domain, transmembra
ne region, cytoplasmic domain (three exons) and 3' UT region. Comparis
on with mouse class-I genes shows that the greatest similarity is to t
he H-2Q, K, D and L genes; it is very different from the TL genes of t
he mouse and rat. A sequence that includes many CT repeats occurs in t
he 3'UT region of RT1.0 and in three to five other class I-hybridizing
fragments. Thus, the MHC-linked region of the rat contains both Q-lik
e and TL-like class-I genes.