ACTIVITY OSCILLATIONS PREDICTED FOR PYRUVATE-DEHYDROGENASE COMPLEXES

Authors
SELIVANOV VA ZAKRZHEVSKAYA DT GOLDSTEIN BN
Citation
Va. Selivanov et al., ACTIVITY OSCILLATIONS PREDICTED FOR PYRUVATE-DEHYDROGENASE COMPLEXES, FEBS letters, 345(2-3), 1994, pp. 151-153
Citations number
15
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
345
Issue
2-3
Year of publication
1994
Pages
151 - 153
Database
ISI
SICI code
0014-5793(1994)345:2-3<151:AOPFPC>2.0.ZU;2-H
Abstract
A kinetic model for the pyruvate dehydrogenase complex is analyzed. Th e model takes into account intermediate channeling through the lipoyl network attached to the complex core, as well as inter-related regulat ory effects of protein X acetylation and enzyme phosphorylation. The m odel predicts undamped oscillations of enzyme activity.