HUMAN INTERLEUKIN-13 ACTIVATES THE INTERLEUKIN-4-DEPENDENT TRANSCRIPTION FACTOR NF-IL4 SHARING A DNA-BINDING MOTIF WITH AN INTERFERON-GAMMA-INDUCED NUCLEAR-BINDING FACTOR
I. Kohler et al., HUMAN INTERLEUKIN-13 ACTIVATES THE INTERLEUKIN-4-DEPENDENT TRANSCRIPTION FACTOR NF-IL4 SHARING A DNA-BINDING MOTIF WITH AN INTERFERON-GAMMA-INDUCED NUCLEAR-BINDING FACTOR, FEBS letters, 345(2-3), 1994, pp. 187-192
The effects of interleukin-13 (IL-13) and interleukin-4 (IL-4) on cell
ular functions were shown to be quite similar. We provide evidence tha
t in monocytes as well as in T lymphocytes both IL-4 and IL-13 activat
e the same recently identified transcription factor NF-IL4 which binds
to the specific responsive element IL-4RE. In addition, we show that
a nuclear factor activated by interferon-gamma also interacts with the
IL-4RE. It differs from NF-IL4 in the electrophoretic mobility of the
complex with DNA, in its DNA-binding specificity and in the proteins
interacting with the DNA sequence. Sensitivity against various enzyme
inhibitors suggests that components of the signal transduction pathway
are shared by all three cytokines.