DICLOFENAC SODIUM MICROCAPSULES - IN-VITRO TESTING CONSIDERATIONS

Despite the great proliferation of microcapsules in the pharmaceutical field, there are no official guidelines for in vitro testing. This la ck of official information means that many devices and processes have to be used to determine accurately the dissolution characteristics of microcapsules. Our objective is to review the ''in vitro'' dissolution tests performed by researchers and to establish the best conditions t o rest diclofenac sodium microcapsules obtained by using a polymeric s olvent extraction method, with three different in vitro systems. Some mathematical adjustments have been made with the results, in order to establish the most appropriate in vitro dissolution system.