COMPARATIVE TRIAL OF ACCEPTABILITY OF BECLOMETHASONE DIPROPIONATE ANDA NEW FORMULATION OF FLUNISOLIDE

A randomized, double-blind, crossover study of a new formulation of fl unisolide nasal spray was performed comparing its acceptability and sa fety to that of aqueous beclomethasone dipropionate nasal spray. The s ingle center study enrolled 100 adults with allergic rhinitis; of thes e, 99 provided valid data for analysis. Each study participant receive d a single dose of each study drug and assessed nasal burning/stinging and other adverse effects. Analysis of patient evaluations revealed n o significant differences in nasal or pharyngeal irritation (P > .05); however, mild aftertaste was present with use of flunisolide (P = .05 9) compared with beclomethasone dipropionate. There was similar accept ance of both study drugs.