OSTEOCLASTOMA-LIKE GIANT-CELL TUMOR OF THE RENAL PELVIS ASSOCIATED WITH PAPILLARY TRANSITIONAL-CELL CARCINOMA

This report documents an uncommon case of osteoclastoma-like giant cel l tumor of the renal pelvis associated with papillary transitional cel l carcinoma, which resulted in the patient's death. A low-grade transi tional papillary carcinoma associated with a prominent osteoclastoma-l ike giant cell tumor was found in the pelvicalyceal system of the righ t kidney in a 69-year-old man. The spindle component of the tumor stai ned for epithelial membrane antigen, indicating an epithelial origin. Positive staining with antibody against p53 protein was observed in bo th tumoral components. Our results suggest that this osteoclastomalike giant cell tumor was truly neoplastic and that the two components cou ld have arisen from an initial monoclonal neoplastic proliferation.