We describe herein a 29-year-old patient who was recognized as having
a xeroderma pigmentosum variant or pigmented xerodermoid in the early
adult life since sunlight sensitivity caused degenerative changes in t
he skin and cutaneous carcinomas. The patient had 11 skin tumours remo
ved over an interval of two years, of which four proved to be squamous
cell carcinoma, one basal cell carcinoma and six precancerous conditi
ons. Then the patient was treated with isotretinoin at a dosage of 2 m
g per kilogram of body weight per day for two years. During two years
of treatment with isotretinoin a further three tumours were removed gi
vind a histological result of basal cell carcinoma and Bowen's disease
s. The patient tolerated well this low dosage retinoid treatment. Only
50 or so of these patients are described in the world literature.