Elderly patients use more medications than younger patients and the tr
end of increasing drug use continues through 80 years of age. Studies
conducted in a variety of settings have shown that patients over 65 ye
ars of age use an average of 2 to 6 prescribed medications and 1 to 3.
4 nonprescribed medications. Success of pharmaceutical and medical res
earch has resulted in an abundance of effective drugs to treat acute a
nd chronic conditions. Most research resulting in the development and
marketing of these medications has been directed at proving the effica
cy and safety of single drug products. Little research has been direct
ed to determine the safety and efficacy of combining multiple medicati
ons to treat concurrent conditions in a single patient. It is known th
at the use of multiple medications increases the risks of adverse drug
reactions, drug-drug interactions, and makes compliance with medicati
on regimens more difficult. Numerous studies have been conducted to be
tter understand factors that are associated with increased drug use in
elderly people. Studies also have been conducted to identify interven
tions that can improve drug treatment for the elderly, and reduce poly
pharmacy. Multiple drug use is common in older people, and may give ri
se to drug related problems. Methods to reduce the risks of polypharma
cy include patient education, physician education, such as education a
nd feedback systems, and regulatory intervention. Continual drug and d
isease monitoring is essential.