MIB-1 EVALUATED PROLIFERATIVE ACTIVITY IN OVARIAN-CANCER WITH RESPECTTO PROGNOSTIC-SIGNIFICANCE

In the present study, tumor tissue of 251 patients with ovarian cancer was immunohistochemically analysed for proliferative activity using t he monoclonal antibody mib-1 and the analyse system CAS 200. The rate of the growth fraction varied from 0% to 71% mib-1 positive tumor cell s with a median of 17%. There was a strongly significant association b etween proliferative activity and the degree of histological different iation (p=0.0005), whereas there was not significant correlation with tumor stage and histological subtypes. Using the median as the cut-off point, patients with higher proliferating tumors (greater than or equ al to 17%) had a statistically significant worse prognosis (p=0.0431). Especially in the group of patients with grade 1 and grade 2 tumors, measurement of the proliferative activity is of help for prediction of the postoperative survival time of patients (p=0.0336), suggesting th at measurement of the growth fraction estimated by mib-1 reflects more closely the degree of tumor differentiation. However, multivariate an alyses cannot confirm these results.