THE INHIBITORY EFFECT OF 8-OH-DPAT ON THE FIRING ACTIVITY OF DORSAL RAPHE SEROTONINERGIC NEURONS IN RATS IS ATTENUATED BY LESION OF THE FRONTAL-CORTEX

Authors
CECI A BASCHIROTTO A BORSINI F
Citation
A. Ceci et al., THE INHIBITORY EFFECT OF 8-OH-DPAT ON THE FIRING ACTIVITY OF DORSAL RAPHE SEROTONINERGIC NEURONS IN RATS IS ATTENUATED BY LESION OF THE FRONTAL-CORTEX, Neuropharmacology, 33(5), 1994, pp. 709-713
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
33
Issue
5
Year of publication
1994
Pages
709 - 713
Database
ISI
SICI code
0028-3908(1994)33:5<709:TIEO8O>2.0.ZU;2-F
Abstract
The dose-response inhibitory effect of 8-OH-DPAT on the firing rate of dorsal raphe serotoninergic neurons was shifted 10-fold to the right after acute fronto-cortical deafferentation. This finding suggests tha t the inhibitory effect of 8-OH-DPAT on the dorsal raphe firing rate m ight be mediated indirectly by the frontal cortex.