THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP

In 1992, we described a second-generation genetic linkage map of the h uman genome. Using 1,267 new microsatellite markers, we now present a new genetic linkage map containing a total of 2,066 (AC)(n) short tand em repeats, 60% of which show a heterozygosity of over 0.7. Statistica l linkage analysis based on the genotyping of eight large CEPH familie s placed these markers in the 23 linkage groups. The map includes 1,26 6 intervals and spans a total distance of 3690 centiMorgans (cM). A to tal of 1,041 markers could be ordered with odds ratios greater that 10 00:1. About 56% of this map is at a distance of 1 cM or less from one of its markers.