PRODUCTION OF 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID USINGSOYBEAN LIPOXYGENASE-1 IN A BIPHASIC OCTANE-WATER SYSTEM

Authors
DROUET P THOMAS D LEGOY MD
Citation
P. Drouet et al., PRODUCTION OF 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID USINGSOYBEAN LIPOXYGENASE-1 IN A BIPHASIC OCTANE-WATER SYSTEM, Tetrahedron letters, 35(23), 1994, pp. 3923-3926
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
23
Year of publication
1994
Pages
3923 - 3926
Database
ISI
SICI code
0040-4039(1994)35:23<3923:PO1AU>2.0.ZU;2-0
Abstract
The synthetic potential of soybean lipoxygenase 1 (LOX 1) for the synt hesis of 13(S) hydroperoxy-9(Z),11(E)-octadecadienoic acid is investig ated in a biphasic medium (octane; berate buffer, pH 9.6) Improvement of the reaction yield (compared to an aqueous system) is observed at v ery high concentrations (20-40 g/L). The regioselectivity of the react ion is not affected by the presence of the organic phase.