A SIMPLE ASYMMETRIC-SYNTHESIS OF 2-SUBSTITUTED 2,3-DIHYDRO-4-PYRIDONES

Authors
STREITH J BOIRON A SIFFERLEN T STREHLER C TSCHAMBER T
Citation
J. Streith et al., A SIMPLE ASYMMETRIC-SYNTHESIS OF 2-SUBSTITUTED 2,3-DIHYDRO-4-PYRIDONES, Tetrahedron letters, 35(23), 1994, pp. 3927-3930
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
23
Year of publication
1994
Pages
3927 - 3930
Database
ISI
SICI code
0040-4039(1994)35:23<3927:ASAO22>2.0.ZU;2-#
Abstract
R pronounced asymmetric induction (db. = 95 %) was observed during met hylation of pyridinium salt 7 with MeMgI which led ultimately to (2R) 2-methyl-2,3-dihydro-4-pyridone 9. This result is best explained by as suming chelate-control during the asymmetric alkylation step.