AMYLIN GIVEN BY CENTRAL AND PERIPHERAL ROUTES INHIBITS ACID GASTRIC-SECRETION

The effect of rat amylin on acid gastric secretion in the pylorus-liga ted, unanesthetized rat system (Shay test) was examined. Amylin admini stered peripherally (2.5, 5, 10, 40, 100, or 160 mu g/kg, SC) or intra cerebroventricularly (1.5, 2.7, or 5 mu g/rat, ICV) decreased acid gas tric secretion in a dose-dependent manner. Central administration of a mylin gave a stronger suppression of gastric secretion than peripheral injection. In addition, ICV-injected amylin inhibited insulin-stimula ted acid gastric secretion and was effective in suppressing acid gastr ic secretion in rats depleted of somatostatin by pretreatment with cys teamine. This study suggests that amylin may participate in the centra l regulation of acid gastric secretion and indicates a possible biolog ical function of amylin as a gastrointestinal peptide.