STEROID-RECEPTOR DOMAIN CONFORMATIONS AND HORMONE ANTAGONISM

Authors
Citation
Mk. Agarwal, STEROID-RECEPTOR DOMAIN CONFORMATIONS AND HORMONE ANTAGONISM, Naturwissenschaften, 81(3), 1994, pp. 115-122
Citations number
81
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
00281042
Volume
81
Issue
3
Year of publication
1994
Pages
115 - 122
Database
ISI
SICI code
0028-1042(1994)81:3<115:SDCAHA>2.0.ZU;2-2
Abstract
Receptor stabilization, activation, dimerization, and binding to cogna te sequences on DNA are possible with antagonists. Tissue-, steroid-, and species-dependent differences in all these parameters, despite ide ntical structure of the receptor from various sources for any one ster oid hormone class, suggest posttranslational modifications of a primar y gene product. Clinically, it is now possible to visualize receptor-s pecific antihormone therapy of various steroid-dependent maladies (can cer of the breast, uterus, or prostate, Cushing's disease, hypertensiv e disorders, etc.) where surgical resection has been hitherto most eff ective. Amelioration of adverse side effects, associated with currentl y available semispecific derivatives, should permit wider applications in a variety of other situations in the near future.