SYNTHESIS OF 2'-DEOXY-2'-ALPHA-MONOFLUOROMETHYL AND TRIFLUOROMETHYL NUCLEOSIDES

Authors
Citation
C. Schmit, SYNTHESIS OF 2'-DEOXY-2'-ALPHA-MONOFLUOROMETHYL AND TRIFLUOROMETHYL NUCLEOSIDES, Synlett, (4), 1994, pp. 241-242
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
09365214
Issue
4
Year of publication
1994
Pages
241 - 242
Database
ISI
SICI code
0936-5214(1994):4<241:SO2ATN>2.0.ZU;2-S
Abstract
Coupling nf 2'-deoxy-2'-alpha-monofluoromethyl and trifluoromethyl rib ose derivatives with bissilylated thymine afforded a mixture of alpha- and beta- nucleosides which were further transformed into their corre sponding pure beta-phosphoramidites.