A NEW APPROACH TO THE ASYMMETRIC-SYNTHESIS OF ALPHA-METHYLTRYPTOPHAN

Citation
C. Cativiela et al., A NEW APPROACH TO THE ASYMMETRIC-SYNTHESIS OF ALPHA-METHYLTRYPTOPHAN, Synlett, (4), 1994, pp. 302-304
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
09365214
Issue
4
Year of publication
1994
Pages
302 - 304
Database
ISI
SICI code
0936-5214(1994):4<302:ANATTA>2.0.ZU;2-X
Abstract
Alpha-methyltryptophan can easily be obtained in enantiomerically pure form through diastereoselective alkylation of a chiral 2-cyanopropano ate followed by the Curtius rearrangement. Non-proteinogenic, unnatura l alpha-amino acids have attracted the attention of numerous researche rs due to the widespread use of these compounds in physical and life s cience. Many synthetic methodologies have already been developed to ob tain a wide range of optically active alpha-amino acids.1