THE APPLICATION OF SOLID DISPERSION TECHNIQUE WITH D-MANNITOL TO THE IMPROVEMENT IN ORAL ABSORPTION OF TRIAMTERENE

Present paper proposes a new system to administer triamterene, a spari ng potassium diuretic which presents absorption problems when administ ered as a free powder, due to its low solubility in water. To increase the dissolution rate and subsequent oral bioavailability of this drug , it has been formulated as solid dispersion. This method involves pre paration by the melting carrier method using D-mannitol as matrix. The se systems were subjected to USP XXII dissolution rate determination. The results revealed a marked dissolution rate increase of included tr iamterene in solid dispersions when compared with micronized drug. Fur ther in vivo assays have demonstrated the absorption efficiency for th e proposed systems when referred to pure drug. In vitro-in vivo correl ation between the parameter T80% (from dissolution rate studies) and t he pharmacokinetic one K(e), has found to be acceptable. All the resul ts obtained make this system suited for further formulation in the pha rmaceutical industry.