Ra. Stockley et al., NEUTROPHIL FORMYL-PEPTIDE RECEPTORS - RELATIONSHIP TO PEPTIDE-INDUCEDRESPONSES AND EMPHYSEMA, American journal of respiratory and critical care medicine, 149(2), 1994, pp. 464-468
Citations number
20
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
A reproducible assay was established to assess the number of formyl-pe
ptide receptors expressed on the surface of human polymorphonuclear le
ukocytes (PMN). Using this assay the number of receptors was shown to
demonstrate wide within- and between-subject variability. However, the
receptor numbers were related to the chemotactic response (r = 0.572)
and degranulation response (r = 0.512) to the peptide formyl-methiony
l-leucyl-phenylalanine. Subsequent studies showed increased receptor n
umbers on PMN from patients with emphysema (median, 459 x 10(3)/cell;
range, 207 to 1,080) as compared with age-matched control subjects (me
dian, 288; range, 168 to 519; p < 0.02), which may explain the increas
ed chemotactic response of the PMN to formyl peptides. This difference
was not observed in patients with bronchiectasis, suggesting that the
increased receptor number is a feature of emphysema. Furthermore, the
increase was largely a feature of smokers with emphysema (median, 463
; range, 362 to 1,080), whereas age-matched smokers without emphysema
had lower numbers of receptors (p < 0.001; median, 332; range, 243 to
411). This observation suggests a mechanism that may explain the susce
ptibility of some smokers to the development of emphysema.