Tr. Silva et Fx. Malcata, ON THE APPROPRIATENESS OF USE OF A CONTINUOUS FORMULATION FOR THE MODELING OF DISCRETE MULTIREACTANT SYSTEMS FOLLOWING MICHAELIS-MENTEN KINETICS, Bioprocess engineering, 10(5-6), 1994, pp. 235-240
The possibility of solving the mass balances to a multiplicity of subs
trates within a CSTR in the presence of a chemical reaction following
Michaelis-Menten kinetics using the assumption that the discrete distr
ibution of said substrates is well approximated by an equivalent conti
nuous distribution on the molecular weight is explored. The applicabil
ity of such reasoning is tested with a convenient numerical example. I
n addition to providing the limiting behavior of the discrete formulat
ion as the number of homologous substrates increases, the continuous f
ormulation yields in general simpler functional forms for the final di
stribution of substrates than the discrete counterpart due to the recu
rsive nature of the solution in the latter case.