SYNTHESIS AND ANTITUMOR-ACTIVITY OF POLYANION-PT-COMPLEXES CONTAININGALICYCLIC AMINES AS LIGANDS

Four polyanion-Pt(II)-complexes, PEE-cis-DACH-Pt, PEE-cis-(ACP)2-Pt, P CP-cis-DACH-Pt, and PCP-cis-(ACP)2-Pt, were synthesized by the reactio ns of polyanions such as ahydropyran-5,6-diyl)(1,2-dicarboxyethylene)] (PEE) and ydropyran-2,6-diyl)-(1,2-dicarboxypropylene)](PCP) with cis- [Pt(amine)2)2](NO3)2, where the amine was 1,2-diaminocyclohexane (DACH ) or aminocyclopropane (ACP). The biological activities of the complex es were measured in vitro against A-459 nonsmall cell lung, Sk-OV-3 ov arian, SK-Mel-2 melanoma, XF-498 CNS, and HCT-15 colon tumor cell line s. The increased life span was measured against L1210 leukemia and fou nd to be 223% for PCP-cis-(ACP)2-Pt(II) at the dose of 25 mg/Kg.