This is a review of the literature on the effects of alcohol on white
matter development. For many years, human and animal studies have repo
rted the vulnerability of developing white matter to the effects of al
cohol. However, until recently, studies on alcohol and white matter we
re limited by existing technology. New technology documenting the pres
ence of neurotransmitter receptors and ion channels on glial cells now
provides a new focus for research on alcohol and white matter develop
ment. New research using new technology should enlarge our knowledge o
f the role of glial cells in brain damage associated with alcohol expo
sure during development.