DEMONSTRATION OF I(17Q) IN METAPHASE AND INTERPHASE OF MALIGNANT HEMATOPOIETIC-CELLS BY FLUORESCENCE IN-SITU HYBRIDIZATION

Authors
SHI GP WEH HJ HOSSFELD DK
Citation
Gp. Shi et al., DEMONSTRATION OF I(17Q) IN METAPHASE AND INTERPHASE OF MALIGNANT HEMATOPOIETIC-CELLS BY FLUORESCENCE IN-SITU HYBRIDIZATION, Cancer genetics and cytogenetics, 73(1), 1994, pp. 17-22
Citations number
15
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
73
Issue
1
Year of publication
1994
Pages
17 - 22
Database
ISI
SICI code
0165-4608(1994)73:1<17:DOIIMA>2.0.ZU;2-8
Abstract
In 10 patients with Various hematopoietic disorders, i(17q) has been s tudied by the technique of fluorescence in situ hybridization (FISH) b oth in metaphase and interphase cells using an alpha-satellite centrom ere-specific probe #17. We observed some minor quantitative difference s between metaphase and interphase cells with regard to the incidence of i(17q) in individual cases and considerable heteromorphism of the s ize of signal of i(17q) among different cases. Our results suggest tha t formation of i(17q) results from a break in the p-arm proximal to th e centromere and that the breakpoints vary from case to case.