COMPETITIVE IN-SITU HYBRIDIZATION IN A MEDIASTINAL GERM-CELL TUMOR

Authors
ALY MS CIN PD JISKOOT P DENEFFE G MARYNEN P VANDENBERGHE H
Citation
Ms. Aly et al., COMPETITIVE IN-SITU HYBRIDIZATION IN A MEDIASTINAL GERM-CELL TUMOR, Cancer genetics and cytogenetics, 73(1), 1994, pp. 53-56
Citations number
18
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
73
Issue
1
Year of publication
1994
Pages
53 - 56
Database
ISI
SICI code
0165-4608(1994)73:1<53:CIHIAM>2.0.ZU;2-X
Abstract
We performed competitive in situ hybridization in a mediastinal germ c ell rumor to identify chromosome 12 aberration(s). DNA from a mouse-hu man somatic hybrid cell line, containing an i(12p) as unique human mat erial, was labeled and used as a probe. Our results confirm that the c hromosome marker, observed in mediastinal germ cell tumor and cytogene tically identified as i(12p), is a true isochromosome of the short arm of chromosome 12.