Tj. Green et Sj. Whiting, POTASSIUM BICARBONATE REDUCES HIGH PROTEIN-INDUCED HYPERCALCIURIA IN ADULT MEN, Nutrition research, 14(7), 1994, pp. 991-1002
The effect of adding sodium bicarbonate (NaHCO3) and potassium bicarbo
nate (KHCO3) on high protein-induced hypercalciuria was evaluated in e
ight healthy male subjects. Subjects were acclimated to high protein a
nd then received in random order, each of the following supplements fo
r four-day periods: 60 g protein (HP), 60 g protein + 90 mmol NaHCO3 (
HP+Na), and 60 g protein + 90 mmol KHCO3 (HP+K). Subjects were then gi
ven a moderate protein (MP) diet. Subjects provided a 24-hour urine sa
mple on Day 3 and Day 4, and a fasting urine and blood sample on Day 5
, of each period. Day 3 and Day 4 calcium excretions were increased du
ring the HP treatment as compared with the MP treatment. During the HP
+K treatment, Day 3 and 4 calcium excretions were greatly reduced rela
tive to the HP treatment. In contrast, during the HP+Na treatment, cal
cium excretion was reduced relative to the HP treatment on Day 3, but
not on Day 4. Serum calcium was significantly increased during the HPK relative to the MP treatment. This study suggests that KHCO3, but no
t NaHCO3, consistently reduces high protein-induced hypercalciuria to
levels seen during ingestion of a moderate protein diet.