30-YEAR EXPERIENCE IN SURGICAL-TREATMENT OF MYASTHENIA (PERSPECTIVES)

The article deals with 30-year experience of the Burdenko Facultative Surgical Clinic in surgical management of generalized myasthemia. The analysis is based on 2,500 cases. This complex disease was worked out in stages, taking into account the advancements of the medical science in the given stage. It is noted that the immediate and late-term resu lts of surgery improved after introduction of the newest methods of ex amination and treatment of patients with mysathenia into practice. Amo ng these methods are CT and MRT, immunohistochemical study, and treatm ent with steroids and immunodepressants. The role and significance of sorption methods and splenectomy in combined treatment of serious form s of myasthenia are pointed out. The elaboration of the clinico-immuno -morphometric criteria allowed the authors to prognosticate the result s of surgical treatment with high authenticity and distinguish two typ es of myasthenia, as a result of which the indications for surgery cou ld be determined more precisely. The authors direct the way to further research in this flield for improvement of the diagnosis and the resu lts of treatment of generalized myasthenia.