EVIDENCE THAT THE IMMEDIATE BIOSYNTHETIC PRECURSOR OF CLAVULANIC ACIDIS ITS N-ALDEHYDE ANALOG

Authors
NICHOLSON NH BAGGALEY KH CASSELS R DAVISON M ELSON SW FULSTON M TYLER JW WORONIECKI SR
Citation
Nh. Nicholson et al., EVIDENCE THAT THE IMMEDIATE BIOSYNTHETIC PRECURSOR OF CLAVULANIC ACIDIS ITS N-ALDEHYDE ANALOG, Journal of the Chemical Society, Chemical Communications, (11), 1994, pp. 1281-1282
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
11
Year of publication
1994
Pages
1281 - 1282
Database
ISI
SICI code
0022-4936(1994):11<1281:ETTIBP>2.0.ZU;2-#
Abstract
(3R, 5R) Clavulanate-9-aldehyde 1 has been detected in Streptomyces cl avuligerus and an NADPH dependent dehydrogenase capable of reducing 1 to clavulanic acid 2 has been isolated from this organism.