PROBING THE D-1,4,5-IP3 D-1,3,4,5-IP4 FUNCTIONAL INTERFACE - SYNTHESIS AND PHARMACOLOGY OF NOVEL D-3-MODIFIED MYOINOSITOL TRISPHOSPHATE ANALOGS/

Authors
FAUQ AH KOZIKOWSKI AP OGNYANOV VI WILCOX RA NAHORSKI SR
Citation
Ah. Fauq et al., PROBING THE D-1,4,5-IP3 D-1,3,4,5-IP4 FUNCTIONAL INTERFACE - SYNTHESIS AND PHARMACOLOGY OF NOVEL D-3-MODIFIED MYOINOSITOL TRISPHOSPHATE ANALOGS/, Journal of the Chemical Society, Chemical Communications, (11), 1994, pp. 1301-1302
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
11
Year of publication
1994
Pages
1301 - 1302
Database
ISI
SICI code
0022-4936(1994):11<1301:PTDDFI>2.0.ZU;2-M
Abstract
To explore the biological significance of the D-3 position phosphoryla tion of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 h ave been synthesized; their binding and Ca2+-release profiles at the I P3-receptor have been studied and shown to correlate with the steric r equirement of the D-3 substituent.