M. Klinge et al., IRREVERSIBLE INHIBITION OF MAMMALIAN AND INSECT PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASES (PHMS), PEPTIDE AMIDATING ENZYMES, BY N-FORMYL AMIDES, Journal of the Chemical Society, Chemical Communications, (11), 1994, pp. 1379-1380
A series of N-formyl amides were synthesized by condensation of N,N-bi
s(trimethylsilyl)formamide with acid chlorides (59-90% yields), or by
reaction of hydroxyglycyl peptides with 90% hydrogen peroxide (45% yie
ld); a number of N-formyl amides which bear a phenyl substituent are m
echanism-based irreversible inactivators of peptidylglycine alpha-hydr
oxylating monooxygenases purified from pig pituitary and from honeybee
heads.