CHROMATOGRAPHIC BEHAVIOR OF NOVEL ZINC(II) CARBOXYLATES WITH NITROGEN-DONOR LIGANDS .1. FORMATES AND ACETATES

The basic characterization of novel Zn(RCOO)(2)L(n)(H2O)(q) compounds including the determination of their melting points, solubility, UV-vi sible absorption spectra, polarity and chromatographic behaviour was p erformed. Thin-layer chromatography with flame ionization detection (F ID) showed an intense FID signal for the zinc(II) carboxylate salts un der examination. Liquid chromatographic analyses were carried out with organic and water-organic mobile phases. Reasonable results were obta ined for analyses on Silasorb SPH Nitrile, Tessek HEMA-Bio 1000CM, LiC hrosorb Si 60 and the best LiChrosorb RP-18 columns. It follows from t he analyses that the retention behaviour of these structurally novel a nd pharmacologically interesting zinc(II) compounds is governed by the chromatographic properties of the corresponding ligand molecule bindi ng. The alkyl chain of the acetate anion has a small effect on the ret ention behaviour of the whole molecule. The increase in retention time is greater with zinc(II) acetates with bound caffeine or phenazone mo lecules and the results confirm that the molecules of zinc(II) carboxy lates move through the entire column.