CELL-SURFACE RECEPTOR FOR ECOTROPIC HOST-RANGE MOUSE RETROVIRUSES - ACATIONIC AMINO-ACID TRANSPORTER

Authors
KAVANAUGH MP WANG H BOYD CAR NORTH RA KABAT D
Citation
Mp. Kavanaugh et al., CELL-SURFACE RECEPTOR FOR ECOTROPIC HOST-RANGE MOUSE RETROVIRUSES - ACATIONIC AMINO-ACID TRANSPORTER, Archives of virology, 1994, pp. 485-494
Citations number
23
Categorie Soggetti
Virology
Journal title
Archives of virology → ACNP
ISSN journal
03048608
Year of publication
1994
Supplement
9
Pages
485 - 494
Database
ISI
SICI code
0304-8608(1994):<485:CRFEHM>2.0.ZU;2-W
Abstract
The cell surface receptor for ecotropic host-range murine leukemia vir uses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter sys tem y(+), which was previously characterized by transport assays. Muta tional analysis indicates that transporter activity is not necessary f or viral reception. Infection of cells with ecotropic retroviruses cau ses only a partial down-modulation of receptor expression on cell surf aces.