BENZOPHENONE PHOTOPROBES FOR PHOSPHOINOSITIDES, PEPTIDES AND DRUGS

Benzophenones (BP) and related aryl ketone photophores have become est ablished as the photoactivatable group of choice for high-efficiency c ovalent modification of hydrophobic regions of binding proteins, inclu ding enzymes and receptors that recognize peptide hormones, (oligo)nuc leotides and nucleosides, phosphoinositides, inositol polyphosphates a nd a wide variety of therapeutic molecules. This review presents the a dvantages of BP as photoaffinity labels and provides specific examples from the last 3 years of applications of BP-containing ligands used i n biochemistry.