REPRODUCTIVE HISTORY AND CANCER OF THE BILIARY-TRACT IN WOMEN

Although reproductive factors have been shown to be related to the com position of bile and functioning of the biliary system, their relation ship with biliary tract cancer has not been studied in detail. Between 1984 and 1987 we conducted a case-control study of 75 women with canc er of the biliary tract and 252 controls from the general population. An interviewer-administered questionnaire was used to collect informat ion on reproductive history. The information was obtained from the res ponders themselves (direct response) or from relatives (indirect respo nse). Our results indicate that younger age at menarche, early age at first pregnancy, higher number of pregnancies and prolonged fertility may enhance the risk of cancer of the biliary tract. Overall, increase d exposure to endogenous oestrogens and progesterone constitutes a hig her risk. (C) 1994 Wiley-Liss, Inc.