DIFFERENT MASS-SPECTROMETRIC APPROACHES IN THE IDENTIFICATION OF ENDOGENOUS METHYLATED PURINE-BASES IN URINE EXTRACTS

Authors
PORCELLI B PAGANI R LORENZINI L DEMARTINO A CATINELLA S TRALDI P
Citation
B. Porcelli et al., DIFFERENT MASS-SPECTROMETRIC APPROACHES IN THE IDENTIFICATION OF ENDOGENOUS METHYLATED PURINE-BASES IN URINE EXTRACTS, Rapid communications in mass spectrometry, 8(6), 1994, pp. 443-450
Citations number
24
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
8
Issue
6
Year of publication
1994
Pages
443 - 450
Database
ISI
SICI code
0951-4198(1994)8:6<443:DMAITI>2.0.ZU;2-X
Abstract
A preliminary identification of endogenous and exogenous methylated pu rine bases in urinary extracts of healthy and tumor-bearing subjects h as been performed using high performance liquid chromatography, and ta ndem mass spectrometry (MS/MS). MS/MS gave particularly fast and sensi tive analyses, allowing the simultaneous and rapid determination of 26 different urinary methylated purines. Both sets of data confirm that tumor-bearing patients show changed levels of methylated purine bases.