SYNTHESIS OF SUBSTITUTED CINNAMOYL-TYRAMINE DERIVATIVES AND THEIR PLATELET ANTI-AGGREGATORY ACTIVITIES

Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-cou pling of substituted cinnamic acid with tyramine or tyramine methyl-1- ether to evaluate PAF-receptor binding antagonistic activities and inh ibitory activities on PAF-induced platelet aggregation with interest o n structure-activity relations. The results show that 3,4-dimethoxy-ci nnamoyl tyramine-amide or its methyl ether have significant PAF-recept or binding antagonistic activity and platelet antiaggregatory activiti es.