K. Yokohata et al., BILIARY MOTILITY - CHANGES IN DETAILED CHARACTERISTICS CORRELATED TO DUODENAL MIGRATING MOTOR COMPLEX AND EFFECTS OF MORPHINE AND MOTILIN IN DOGS, Digestive diseases and sciences, 39(6), 1994, pp. 1294-1301
The temporal relationship of biliary motility to the duodenal migratin
g motor complex and effects of morphine and motilin were studied in Ji
ve dogs prepared with a duodenal cannula. Common bile duct, sphincter
of Oddi, and duodenal manometry were performed awake. Sphincter of Odd
i phasic contractions occurred even during the quiescent period of duo
denal phase I and its activity increased from phase II to III. Minimum
basal pressure of sphincter of Oddi and common bile duct pressure dec
reased from phase I to phase III. Both morphine and motilin induced pr
emature phase III in the sphincter of Oddi and duodenum. Latencies of
the effect were 0.2 min for morphine and 3.2 min for motilin (P < 0.01
). After morphine, vigorous continuous contractions with high basal pr
essure occurred being interrupted by brief and repeated inactive perio
ds, similar to spontaneous phase III. Motilin-induced phase III appear
ed indistinguishable from spontaneous phase III. Although both agents
induced phase III in the sphincter of Oddi, differences in the latency
and contraction pattern suggest different mechanisms of action of the
se agents on the sphincter of Oddi.