BILIARY MOTILITY - CHANGES IN DETAILED CHARACTERISTICS CORRELATED TO DUODENAL MIGRATING MOTOR COMPLEX AND EFFECTS OF MORPHINE AND MOTILIN IN DOGS

The temporal relationship of biliary motility to the duodenal migratin g motor complex and effects of morphine and motilin were studied in Ji ve dogs prepared with a duodenal cannula. Common bile duct, sphincter of Oddi, and duodenal manometry were performed awake. Sphincter of Odd i phasic contractions occurred even during the quiescent period of duo denal phase I and its activity increased from phase II to III. Minimum basal pressure of sphincter of Oddi and common bile duct pressure dec reased from phase I to phase III. Both morphine and motilin induced pr emature phase III in the sphincter of Oddi and duodenum. Latencies of the effect were 0.2 min for morphine and 3.2 min for motilin (P < 0.01 ). After morphine, vigorous continuous contractions with high basal pr essure occurred being interrupted by brief and repeated inactive perio ds, similar to spontaneous phase III. Motilin-induced phase III appear ed indistinguishable from spontaneous phase III. Although both agents induced phase III in the sphincter of Oddi, differences in the latency and contraction pattern suggest different mechanisms of action of the se agents on the sphincter of Oddi.