Objective: To assess ipsilateral spermatogenesis in men with malignant
and benign nongerm cell tumors of the testis. Design, Patients: Histo
logic review of radical orchiectomy specimens performed for 20 men wit
h malignant nongerm cell tumors and 15 with benign testicular lesions,
including five Leydig cell tumors with benign clinical features. Main
Outcome Measures: Degree of spermatogenesis was determined on a 1 to
10 scale, with 10 representing mature sperm within a seminiferous tubu
le. For each patient ''near'' and ''far'' scores were determined by ob
taining the mean score of 50 tubules adjacent (<3 mm) to the tumor and
50 tubules distant (>3 mm) from the tumor, respectively. Results: Tot
al, near, and far scores were all lower for malignant tumors than for
benign lesions. Scores for Leydig cell tumors were similar to benign l
esions. Malignant tumors demonstrated a gradient effect, with greatest
impairment of spermatogenesis occurring adjacent to tumor. In contras
t, a distinction between near and far scores was not observed for beni
gn lesions or Leydig cell tumors. Conclusions: Malignant nongerm cell
tumors of the testis were associated with significant impairment of ip
silateral spermatogenesis, particularly in areas adjacent to tumor. Th
ese findings are similar to those observed for testicular germ cell tu
mors, suggesting a generalized negative influence on ipsilateral sperm
atogenesis by malignant tumors.