SEVERE RHABDOMYOLYSIS IN A PATIENT RECEIV ING LOVASTATIN, DANAZOL ANDDOXYCYCLINE

Combinations of lovastatin and other drugs have been reported to cause rhabdomyolysis and myoglobinuria: The authors report such a case in a 72-year-old man who had been receiving atenolol, acetylsalicylic acid (ASA), dipyridamole, lovastatin, danazol, prednisone and doxycycline. The ASA, lovastatin and danazol were discontinued. The symptoms resol ved, and laboratory test results were normal within 2 weeks. Lovastati n was strongly suspected; danazol was the most likely potentiator by d iminishing the metabolism of lovastatin and its metabolites in the liv er or by having a direct toxic effect on the muscles.