EARLY HCG-INDUCED DESENSITIZATION OF RAT OVARIAN LH HCG RECEPTORS IS ASSOCIATED WITH ALTERED PHYSICAL STATE OF MEMBRANES/

Authors
KOLENA J SCSUKOVA S TATARA M JASEM P
Citation
J. Kolena et al., EARLY HCG-INDUCED DESENSITIZATION OF RAT OVARIAN LH HCG RECEPTORS IS ASSOCIATED WITH ALTERED PHYSICAL STATE OF MEMBRANES/, FEBS letters, 346(2-3), 1994, pp. 221-224
Citations number
26
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
346
Issue
2-3
Year of publication
1994
Pages
221 - 224
Database
ISI
SICI code
0014-5793(1994)346:2-3<221:EHDORO>2.0.ZU;2-P
Abstract
Injection of pseudopregnant rats with pharmacological doses of hCG pro duced desensitization of adenylylcyclase and steroidogenic systems in ovarian membranes and luteal cells. Membrane lipid rigidity, as determ ined by fluorescence polarization of DPH, decreased as early as 0.5 h after injection of hCG. Desensitization also modified the differential scanning calorimetric profile characteristic of control membranes. Th e accessibility of ovarian LH/hCG receptors was unchanged. The results indicate that the hCG-induced decrease of membrane lipid rigidity is preceded by the process of desensitization of the rat ovary.