APPLICATION OF ARTIFICIAL NEURAL NETWORKS FOR PROKARYOTIC TRANSCRIPTION TERMINATOR PREDICTION

Artificial neural networks (ANN) to predict terminator sequences, base d on a feed-forward architecture and trained using the error back prop agation technique, have been developed. The network uses two different methods for coding nucleotide sequences. In one the nucleotide bases are coded in binary while the other uses the electron-ion interaction potential values (EIIP) of the nucleotide bases. The latter strategy i s new, property based and substantially reduces the network size. The prediction capacity of the artificial neural network using both coding strategies is more than 95%.