A GENERAL-METHOD FOR THE SOLID-PHASE SYNTHESIS OF UREAS

Authors
HUTCHINS SM CHAPMAN KT
Citation
Sm. Hutchins et Kt. Chapman, A GENERAL-METHOD FOR THE SOLID-PHASE SYNTHESIS OF UREAS, Tetrahedron letters, 35(24), 1994, pp. 4055-4058
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
24
Year of publication
1994
Pages
4055 - 4058
Database
ISI
SICI code
0040-4039(1994)35:24<4055:AGFTSS>2.0.ZU;2-I
Abstract
A general method for the solid-phase synthesis of ureas has been devel oped. The key intermediate being a p-nitrophenylcarbamate which is tra nsformed into the urea by reaction with primary or secondary amines. T he products obtained are of high chemical purity.