REGIOSELECTIVE N-METHYL CARBON LITHIATION OF N-BOC-METHYLALKYLAMINES - EXPEDIENT SYNTHESIS OF UNSYMMETRICAL AMINES

Authors
SNIECKUS V ROGERSEVANS M BEAK P LEE WK YUM EK FRESKOS J
Citation
V. Snieckus et al., REGIOSELECTIVE N-METHYL CARBON LITHIATION OF N-BOC-METHYLALKYLAMINES - EXPEDIENT SYNTHESIS OF UNSYMMETRICAL AMINES, Tetrahedron letters, 35(24), 1994, pp. 4067-4070
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
24
Year of publication
1994
Pages
4067 - 4070
Database
ISI
SICI code
0040-4039(1994)35:24<4067:RNCLON>2.0.ZU;2-L
Abstract
The regioselective lithiation and functionalization at the N-methyl gr oup of N-t-Boc-N-methylalkylamines 3 and 5 are shown with a variety of electrophiles to give products 4 and 6, respectively, thus providing a convenient methodology for the elaboration of unsymmetrical amines.