A SYNTHETIC APPROACH TO THE PSEUDOPTEROSINS USING CASCADE TECHNOLOGY

Authors
HARROWVEN DC DENNISON ST HOWES P
Citation
Dc. Harrowven et al., A SYNTHETIC APPROACH TO THE PSEUDOPTEROSINS USING CASCADE TECHNOLOGY, Tetrahedron letters, 35(24), 1994, pp. 4243-4246
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
24
Year of publication
1994
Pages
4243 - 4246
Database
ISI
SICI code
0040-4039(1994)35:24<4243:ASATTP>2.0.ZU;2-Z
Abstract
A rapid synthetic entry towards the pseudopterosins, a class of diterp enes which display potent anti-inflammatory and analgesic properties, is described. The key feature of this approach is the use of a sequent ial intramolecular, Lewis acid mediated Friedel-Crafts alkylation - Fr iedel-Crafts acylation sequence, viz 14 to 15, to establish the tricyc lic carbon framework.