VARIABILITY OF LIPID PHENOTYPES IN HYPERURICAEMIC-HYPERLIPIDEMIC PATIENTS

We studied changes in the hyperuricaemia-associated lipid phenotypes o f primary hyperuricaemic-hyperlipidemic patients, none of whom was obe se, hypertensive or an alcohol drinker. The patients were monitored fo r three months during which they were placed on a strict diet. The res ults obtained showed that phenotype IIB was most frequently associated with hyperuricaemia, followed by phenotypes IV and IIA. Lipid phenoty pes were found to change in most patients during the study, even thoug h most of them remained hyperuricaemic-hyperlipidemic. We also determi ned apoprotein B in each determination and found that over half the pa tients possessed increased levels of this apolipoprotein. The results confirm that hyperuricaemia is not associated to a unique lipid phenot ype since the phenotype of a given patient may change with time, even in the absence of propitiating external factors.