CENTRAL-NERVOUS-SYSTEM LUPUS - CONCOMITANT OCCURRENCE OF MYELOPATHY AND COGNITIVE DYSFUNCTION

Reported are two cases of patients with central nervous system systemi c lupus erythematosus (SLE) with clinical features of a myelopathy con firmed by magnetic resonance imaging (MRI). In one case, further evalu ation including Single Photon Emission Computerized Tomography (SPECT) and neuropsychological testing, indicated higher cortical deficits wh ich improved after treatment with monthly pulse intravenous cyclophosp hamide. Subsequent cessation of cyclophosphamide was associated with f urther progression of the neurological disease in this patient.