R. Tehiler et al., REDUCED VITAMIN-A TOLERANCE IN A HYPERLIPEMIA PATIENT WITH RAPID DESTRUCTIVE AND HYPEROSTOTIC OSTEOARTHRITIS OF THE HIP, Clinical rheumatology, 13(2), 1994, pp. 293-298
A 59-year-old patient suffering from hyperlipidaemia developed a chron
ic vitamin A intoxication syndrome after ingestion of 30000 IE retinol
/daily over a period of six years. Functional disability of the right
hip was caused by radiologically documented hyperostosis of the acetab
ular circumference. Finally, a prosthesis had to be implanted because
of rapid destructive osteoarthritis of the right hip. Implications of
vitamin A for rheumatological management are discussed.