STUDY OF THE MUTUAL EFFECTS OF SULFADIAZINE AND CIPROFLOXACIN ON THEIR UPTAKES BY PSEUDOMONAS-AERUGINOSA

Authors
RICHARDS RME REID RG HAMILTON VES XING DKL
Citation
Rme. Richards et al., STUDY OF THE MUTUAL EFFECTS OF SULFADIAZINE AND CIPROFLOXACIN ON THEIR UPTAKES BY PSEUDOMONAS-AERUGINOSA, Journal of Pharmacy and Pharmacology, 46(6), 1994, pp. 530-532
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
46
Issue
6
Year of publication
1994
Pages
530 - 532
Database
ISI
SICI code
0022-3573(1994)46:6<530:SOTMEO>2.0.ZU;2-L
Abstract
A high-performance liquid chromatography (HPLC) assay was developed fo r ciprofloxacin and sulphadiazine in Iso-sensitest broth. Combining th e HPLC assay with cell dry-weight determinations indicated that both c ompounds were able to enhance the uptake of the other by log phase Pse udomonas aeruginosa cultured in the presence of the compounds. It is h ypothesized that the increased bacterial uptakes are the reason for th e enhanced antibacterial activity previously reported for combinations of ciprofloxacin and sulphadiazine.