RADIOIODINATED METAIODOBENZYLGUANIDINE - A REVIEW OF ITS BIODISTRIBUTION AND PHARMACOKINETICS, DRUG-INTERACTIONS, CYTOTOXICITY AND DOSIMETRY

Since the introduction of radioiodinated metaiodobenzylguanidine in 19 80, considerable research has been performed, both in the chemical fie ld and in medical sciences. However, despite the wide use of radioiodi nated metaiodobenzylguanidine, knowledge about its pharmacology is sti ll limited. This paper reviews the biodistribution and pharmacokinetic s, drug interactions, cytotoxicity and dosimetry of radioiodinated met aiodobenzylguanidine. Iodine-131 metaiodobenzylguanidine therapy is in general well tolerated, but its effectiveness needs improvement. Also whole-body dosimetry as part of treatment planning needs to be improv ed. Future prospects on these items are included in this review.