T. Suzuki et al., A STUDY ON SONODYNAMIC THERAPY ANTITUMOR EFFECT OF NOVEL SONODYNAMIC COMPOUNDS UNDER ULTRASOUND, Heterocycles, 38(6), 1994, pp. 1209-1211
Diacetylhematoporphyrin-mitomycin C conjugate ( diAc-Hp-MMC ) (1) prep
ared by a condensation of diacetylhematoporphyrin with MMC in the pres
ence of N, N- dimethylaminopyridine and dicyclohexylcarbodiimide, and
two of the pyridocarbazole derivatives (8) and (9) were provided for s
onodynamic compounds and these compounds were found to show excellent
cell-killing effect, comparing to those of the known sonodynamc compou
nd hematoporphyrin, Hp 2HCl (2), Di-Ac-Hp (3), Hp-Co (4), Hp-Fe (5), A
crinol ( 6) and MMC (7).